Coagulation Changes during Experimental Hemorrhagic Shock
نویسندگان
چکیده
منابع مشابه
The cerebral microcirculation is protected during experimental hemorrhagic shock.
OBJECTIVE Decreases in buccal microcirculation are indicative of the severity of hemorrhage, but incidental observations suggest that this may not apply to the cerebral microcirculation. We therefore hypothesized that the cerebral microcirculation may be preserved in hemorrhagic shock in which systemic and buccal microcirculatory flow are reduced. We propose to relate changes in the macrocircul...
متن کاملExperimental models of hemorrhagic shock: a review.
Massive blood loss leading to hypovolemic shock is still a life-threatening situation. Recently, a great number of investigations have been conducted in order to understand the pathophysiological and immunological changes taking place during shock and to develop treatment strategies. These preclinical trials are based on animal studies. Although a wide spectrum of species and experimental model...
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BACKGROUND Hemorrhagic shock contributes to coagulopathy after trauma. We investigated daily changes of coagulation components and coagulation function for 5 days in hemorrhaged and resuscitated pigs. METHODS Fourteen pigs were randomized into the sham control (C) and the hemorrhage and lactated Ringer's resuscitation (H-LR) groups. On day 1, hemorrhage was induced in the H-LR group by bleedi...
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demonstration using tranylcypromine, a similar demonstration by others, and a direct demonstration in which PGI2 was locally applied to injured vessels in hamster cheek pouch. Our data thus offer a different type of supporting evidence on the capacity of PGI2 to influence platelet aggregation in vivo. We have, in addition, extended previous data to another organ and another species, suggesting ...
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ژورنال
عنوان ژورنال: Annals of Surgery
سال: 1966
ISSN: 0003-4932
DOI: 10.1097/00000658-196608000-00004